EFFECT OF BIFENTHRIN AND D- RIBOSE- L CYSTEINE, CO-TREATMENT ON SERUM INFLAMMATORY BIOMARKERS OF WISTAR RATS
Abstract
Bifenthrin, a widely used pyrethroid pesticide, has been implicated in inflammatory
responses. This study investigated the effect of D-ribose-L-cysteine on Bifenthrininducedchanges
in serum inflammatory biomarkers of adult male Wistar rats. Twenty-eight
rats (100-230 g) were randomly divided into four groups of seven rats each: Group (i) serve
as normal control, Group (ii) Bifenthrin (3 mg/kg body weight), Group iii D-Ribose-Lcysteien
only (200 mg/kg body weight), and Group (iv) D-Ribose L- cysteine + Bifenthrin +
post treatment (3 mg/kg body weigh) Were treated orally for 14 days respectively. And
Bifenthrin followed by D-Ribose-cysteine co-treatment. Rats where sacrificed under
chloroform anesthesia and serum samples were prepared for estimation of caspase-3. The
results for caspase 3, tumor necrosis factor alpha (TNF-α), and interleukin 6 (IL-6) show that
there was a statistical significant (P < 0.05) increases in caspas-3, TNF-α and IL-6 activity of
the Bifenthrin induced group when compared with the normal control group, while the
Bifenthrin-RibCys co-treated group recorded statistically significant (P < 0.05) decreases in
caspas-3, TNF-α and IL-6 activity when compared with the Bifenthrin induced group. In
conclusion, the findings suggest that the protective effect of RibCys is largely mediated
through enhancement of glutathione synthesis and suppression of oxidative stress–driven
inflammatory pathways. Therefore, RibCys may serve as a promising therapeutic agent in
mitigating pesticide-induced systemic inflammation and its associated health risks.
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