EFFECT OF AQUEOUS EXTRACT OF GARLIC (ALLIUM SATIVUM) ON SOME HAEMATOLOGICAL INDICES IN ALBINO WISTAR RATS
Abstract
The aim of this study was to evaluate the effect of aqueous extract of garlic on some
haematological indices in Albino Wistar rats. The study was done using fifteen (15) female
Wistar rats of body weight (90-150g). The rats were divided into three (3) groups. Group I:
Normal control group was treated with only feed and 0.2ml of distilled water, Group II: Garlic
extract high dose group was treated with 600mg/kg and Group III: Garlic extract low dose
group was treated with 300mg/kg. Blood samples were collected via cardiac puncture 12 hours
after last feeding and administration (overnight fast). The animals were urethanized and whole
blood obtained by cardiac puncture into non-heparinised tubes were allowed to clot for 2 hours
until needed for haematological analyses. The parameters evaluated include RBC, PCV, HB,
WBC, PLT, MCV, MCH and MCHC. The result showed that RBC, PCV, Hb, WBC, and PLT
the high dose garlic group was decreased significantly (p0.05) compared to control and the low
dose. However, there was no significant difference in MCV, MCH and MCHC among the
groups. From the results, it can be concluded that garlic may reduce RBC count, PCV, Hb, but
may not have effect on WBC count, platelet count, MCV, MCH, and MCHC particularly at
high doses. Therefore, it should be taken with moderation.
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