ASSESSMENT OF THE EFFECT OF FRACTIONATION GUIDED OF METHANOL EXTRACT OF PEAR LEAF (PYRUS COMMUNIS) ON SOME PATHOGENIC MICROBES
Abstract
ABSTRACT
This study investigated the antimicrobial activity of the methanol extract of Pyrus communis (pear) leaves against selected pathogenic microorganisms, including Lactobacillus species, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Shigella, and Salmonella typhimurium. The extract was fractionated into six portions and tested for antimicrobial activity using standard microbiological methods. The results revealed variable inhibitory effects across the fractions, with notable activity observed against Shigella, Pseudomonas aeruginosa, and Salmonella typhimurium. Fraction 3 exhibited the highest activity against Shigella, while moderate activity was observed against Pseudomonas aeruginosa and Salmonella typhimurium in several fractions. Limited antifungal activity was noted against Candida albicans. The findings suggest that Pyrus communis leaves contain potent phytochemicals with antimicrobial potential and may serve as a valuable source of natural therapeutic agents. Further phytochemical and in vivo studies are recommended to validate and expand on these findings.
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