EFFECT OF ETHANOL LEAF EXTRACT OF ANDROGRAPHIS PANICULATA ON SERUM ADIPONECTIN AND HOMA-IR INDEX IN STREPTOZOTOCIN-INDUCED DIABETIC WISTAR RATS
Abstract
ABSTRACT
This study aims to investigate the effect of ethanol leaf extract of Andrographis paniculata on HOMA-IR index in streptozotocin-induced diabetic wistar rats. A total of twenty-five (25) wistar rats were used for the experiment. Twenty five (25) wistar rats were grouped (A) Normal control and (B) diabetic induced group. The rats were further grouped into: Group I: normal control animals fed with standard rat pellets and tap water for fourteen days (21 days), GroupII: (Negative control) diabetic control animals induced STZ for seven days and daily oral administration of 0.2% twin 80 for fourteen days (21 days), Group III:: induced diabetes with streptozotocin for seven days and treated with metformin (200mg/kg body weight) orally for 21 days, GroupIV: induced diabetes with streptozotocin for seven days and administered orally 500mg/kg body weight Andrographis paniculata ethanol leaf extract daily for 21 days, Group V: induced diabetes with streptozotocin for seven days and administered orally 1000mg/kg body weight Andrographis paniculata ethaleaf extract daily for 21 days. The results showed there was higher HOMA-IR index (p
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