EVALUATION OF THE EFFECT OF BRYOPIIYLLUM PINNATUM ON OXIDATIVE STRESS BIOMAKERS AND COGNITIVE IMPAIRMENT IN ALBINO RATS
Abstract
Schizophrenia, a severe neuropsychiatric disorder, imposes a substantial societal burden due to its complex symptoms. This study explores the potential therapeutic effects of Bryophyllum pinnatum extract in addressing ketamine-induced neurotoxicity, focusing on oxidative stress markers and hippocampal histological changes. Using a preclinical animal model, sixty adult male Wistar rats underwent various treatment protocols over three weeks. Biochemical analysis revealed that Bryophyllum pinnatum extract significantly increased glutathione levels and decreased malondialdehyde levels, indicating its antioxidant properties. Histological examination of hippocampal tissue showed varying degrees of tissue protection with extract treatment, suggesting dose-dependent neuroprotective effects. These findings highlight the potential of Bryophyllum pinnatum as a natural remedy for schizophrenia-related neurobiological abnormalities. Further research is needed to understand its mechanisms and evaluate its efficacy in clinical settings. Bryophyllum pinnatum shows promise as a novel therapeutic intervention for schizophrenia and related conditions, offering hope for improved outcomes and quality of life.
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