HEPATOPROTECTIVE EFFECT OF AQUEOUS LEAVE EXTRACT OF MORINGA LEAF (MORINGA LUCIDA) ON PLASMODIUM BERGHEI INFECTED WISTAR ALBINO RATS
Abstract
This study was carried out to evaluate the effect of aqueous extract of Morinda lucida leave on the liver enzyme of plasmodium berghei infected rats. Twenty five adult wistar rats were divided into five groups: normal control (Group A), treated with 200mg/kg extract (Group B), treated with 400mg/kg extract (Group C), standard control with Amatem soft gel (Group D), and negative control (Group E). Liver function was assessed by measuring serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP). Body weight changes were monitored throughout the treatment period.The study revealed significant hepatoprotective effects of Moringa lucida extract. AST levels remained within normal ranges in treatment groups (22.0±2.65 to 35.0±1.26 IU/L) compared to the negative control (47.0±2.62 IU/L). ALT levels were well-controlled in all treatment groups (14.0±0.56 to 16.0±3.32 IU/L) versus the negative control (54.0±2.11 IU/L). ALP showed progressive increases across treatment groups but remained significantly lower than in untreated infected rats (274.0±2.53 IU/L). Body weight analysis demonstrated better weight maintenance in treated groups compared to untreated controls. These findings support the traditional use of Moringa lucida in malaria management and suggest its potential as an adjuvant therapy.
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