ANTIOXIDANT EFFECT OF G. LATIFOLIUM EXTRACT ON BPH IN WISTAR RAT
Abstract
The aim of this study is to evaluate the antioxidant effect of Gongronema latifolium ethanol leave extract on testosterone propionate induced-benign prostate hyperplasia in Wistar rats. A total of twenty eight (28) mature Wistar rats weighing between 200-300g were grouped into four (4) with seven (7) rats each. Group I served as normal control and received 0.4mni of distilled water. Group II served as the BPH control group. Group Il to IV animals received subcutaneous injection of 3mg/kg testosterone for two weeks. after which group II were treated with Gongronema latifolium (1 50mg/kg body weight). Group IV: BPH rats were treated with Smg/70kg Finasteride (standard drug for treatment of Benign Prostate Hyperplasia) forfour weeks. All animals were euthanized on the 29th day, following an overnight fast and blood samples obtained for biochemical analysis. The result obtained showed that induction of BPH (p
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