PROTECTIVE EFFECTS OF 50 MG/ KG MONODORA TENUIFOLIA SEED EXTRACT ON ALCOHOL-INDUCED LIVER AND KIDNEY DAMAGE IN MALE WISTAR RATS
Abstract
Excessive alcohol consumption is a major cause of liver and kidney injury through oxidative stress, lipid perioxidation and disruption of metabolic function. Monodora tenuifolia is a medicinal plant which contains phytochemicals such as alkaloids, flavonoids, tannins etc. it is known to have antioxidant and inf lammatory properties. The aim of this study is to investigate the effects of high-dose Monodora tenuifolia seed extract in alcohol-induced liver and kidney damage in male wistar rats. Fifteen rats were divided into three groups which are the control, alcohol group, alcohol + high-dose MTSE. The animals were administered with 43% alcohol for five days and given treatment immediately for fourteen days. Also the blood were collected through cardiac puncture and centrifuged to be converted to serum. It was observed that high-dose Monodora tenuifolia seed extract causes a reduction in serum creatinine and serum urea. It also leads to a reduction in the activity of aspartate aminotransferase and alanine aminotransferase enzymes. High-dose Monodora tenuifolia seed extract exhibit protective effects against alcohol-induced toxicity because of its antioxidant and anti-inflammatory properties. It also helps to reduce oxidative stress which causes cellular damage.
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