EFFECT OF ETHANOL EXTRACT OF PILIOSTIGMA THONNINGII LEAF ON KIDNEY OXIDATIVE BIOMARKERS OF CYCLOPHOSPHAMIDE INDUCED IMMUNO COMPROMISED RATS
Abstract
This research was aimed at assessing the effects of administration of ethanol extract of piliostigma thonningii leaf on kidney oxidative biomarkers (malondialdehyde (MDA), superoxide dismutase (SOD), catalase) in cyclophosmaide- induced immune suppressed rats. Thirty-five (35) Wister male rats were allowed to acclimatize for a period of 7 days, in a well ventilated room at room temperature and relative humidity of 29ºC and 70% respectively with 12 hours natural light-dark cycle. They were allowed food and water ad libitum. Good hygiene was maintained by daily cleaning and removal of fasces and spills from their cages. The twenty-five (25) rats were randomly divided into five (5) groups, with five (5) animals per group and treated for a period of fourteen (14) days. Group A (normal control) was fed with normal feed and distilled water, Group B: immune compromised rats (induced with cyclophosphamide) without treatment (immune compromised control), group C: immune compromised rats treated with immunal (standard control). Group D: immune compromised rats with 200 mg/kg bwt ethanol leaf extract p. thonningii extracts (ELEPT1). Group E: immune compromised rats with 400 mg/kg bwt ethanol leaf extract P. thonningii extracts (ELEPT2). Immunosuppression in Wistar rats was induced interperitoneal administration of 10mg/kg b.wt of cyclophosphamide for 7 days to induce immunosuppression in designated rats groups. The results reveals that the extract piliostigma thonningii significantly (P
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