ANTI ULCER POTENTIAL OF HONEY ON ETHANOL INDUCED ULCERATED ALBINO RATS

An ulcer is a lesion/erosion on the epithelial mucosa that extends through the muscolaris mucosa into the submucosa or deeper. The purpose of this research is to assess honey's possible qualities and examine its effects on ulcerated albino rats produced by ethanol. 16 albino rats where randomly divided into 5 groups with each group consisting of 3 rats and were subjected to oral treatment once daily for 21 days. After the 21 days, the rats fasted overnight and were weighed to get the final weight. Then they were induced with 1ml (70%) ethanol to cause ulcer. 4 hours later, the rats were suffocated with chloroform to weaken them, then cervical dislocation was carried out. The results shows stomach gastric level in treated and non treated albino rats where group A (2ml), group B(1ml), group C (5ml), while group D (Positive control)were induced but not treated and group E ( negative control) were not induced and not treated. The potential ameliorative activity of honey is seen in group A with the value of 42.56±13.50 which falls within the normal range of gastrin level. From the results, group A and C which were treated with 2ml and 5ml of honey respectively, shows a greatly ameliorative ulcer scores of 0.00 compared to group B 1ml (1.00) and group D ( not treated), 0.75. In conclusion, honey remarkable and dose- dependently protects the gastric mucosa against ethanol triggered damage. The antioxidant protection is a pointer for scavenging the free radicals formed by ethanol. Honey showed potential in regulating gastric acid secretions, this reducing acidity levels in the stomach and providing a more favorable environment for healing