EFFECT OF ADMINISTERING TRAMADOL HCL AND PROCESSED MILK ON THE CARDIAC PROFILE OF WISTER RATS

This study investigates the effect of administering tramadol HCl and processed milk on the cardiac profile of rats,focusing on changes in body weight and cardiac microstructure.Twenty(20)adult male albino rats were divided into four groups: group i control.group ii 5mg/kg tramadol-only,group iii 10mg/kg processed milk- only,and tramadol+processed milk.Tramadol and processed milk were administered orally for 3 weeks.Body weight was recorded at the beginning and end of the treatment period.Following the treatment period,the heart was harvested and examined histologically to assess structural changes.Histological analysis revealed normal histomorphology of the heart in the control group.The tramadol-only group displayed degeneration with severe atrophy of cardiac fibres and focal aggregate of inflammatory cells.The tissue looks pale with significant changes when compared with the control.The processed milk-only group showed mild fatty change but otherwise normal cardiac features.In the tramadol +processed milk group,mild atrophy of cardiac fibres.However tissue looks better when compared with group ii that received only tramadol,with no significant changes compared to the control group.The control,tramadol-only,and processed milk-only groups showed an increase in final body weight compared to the initial weight,while the tramadol + processed milk group did not exhibit significant weight changes.These findings suggest a potential protective role of processed milk against tramadol-induced cardiotoxicity,warranting a further research to explore its therapeutic potential in clinical settings.