EVALUATION OF PARACETAMOL TABLET FORMULATED WITH CO-PROCESSED EXCIPIENT
Abstract
ABSTRACT
A great number of pharmaceutical excipients, both natural and synthetic including the co-processed excipient are available to meet demands of the rapid development of pharmaceutical industry.
The aim of this present study is to develop a novel multifunctional pharmaceutical excipient for direct compression
(DC) of paracetamol. Methods: The novel excipient was prepared by coprocessing Microcrystalline cellulose, Dibasic calcium phosphate and calcium carbonate into granules using wet granulation . DC was applied in preparing different batches of paracetamol tablets with drug excipient. Both the blended mixture of paracetamol and the excipient powder and the tablets formulated were evaluated for their physicochemical properties including bulk, tapped and particle densities, Hausner's ratio, Carr's index, angle of repose, flow rate, while the tablets formulated were evaluated for uniformity of weight, hardness, friability, disintegration time. The Results: The blended mixture of the co-processed novel excipient and paracetamol mixture exhibited excellent flow property. Formulated tablets were of good quality with regard to weight,friability, hardness, and disintegration time. Conclusion: The paracetamol tablets developed in this study was found to be a promising directly compressible.
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