EVALUATION OF POSSIBLE CHANGES IN LIVER ENZYMES ACTIVITY IN ANGIOTENSIN II ADMINISTRATION AND HESPERIDIN SUPPLEMENTATION IN FEMALE WISTAR RATS
Abstract
This study aimed to evaluate the effects of hesperidin supplementation on liver enzyme activity and histological changes in female Wistar rats subjected to angiotensin II-induced liver toxicity. The experiment assessed the activity of key liver enzymes, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and gamma-glutamyl transferase (GGT), alongside histological examination of liver tissue. Results demonstrated that hesperidin supplementation did not significantly alter the levels of AST, ALT, ALP, or GGT in most cases. However, histological analysis suggested that hesperidin may offer partial protection against liver damage, although it was not entirely protective. The hepatoprotective effect of hesperidin, when compared to telmisartan, an angiotensin receptor blocker, was insufficient in fully preventing liver injury caused by angiotensin II. These findings provide insights into the limited protective role of hesperidin in angiotensin II-induced liver toxicity and emphasize the need for further investigation into potential therapeutic approaches.
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