EFFECT OF ETHANOL EXTRACT OF PILIOSTIGMA THONINGII LEAF ON HAEMOSTATIC INDICES IN CYCLOPHOSPHAMIDE IMMUNO COMPROMISED RATS
Abstract
Piliostigma thonningii is a medicinal plant with proven anti-malarial, anticough, antisnake, anti-inflammatory and antihelmintic potentials. This present study is aimed at ascertaining the effect of ethanol extract of P. thonningii leaf on haemostatic indices in cyclophosphamide immuno compromised rat. Thirty-five (40) male wistar albino rats ranging from180-200g were randomly assigned into group (A-D) of five animals each. Groups(B-D) were administered 1ml of ethanol extract via oral rout corresponding to 50, 100 and 200mg/Kg/body weight, while group A (control) received 1ml of distilled water orally. Rats in all groups were sacrificed 24hours after the experimental periods of 21days of oral administration of the extract. The extract significantly (p
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