COMPARATIVE EFFICACY OF PEPEROMIA PELLUCIDA AND DIAZEPAM ON PAIN IN PENTYLENETETRAZOL INDUCE EPILEPTIC MICE MODEL

Epilepsy a prevalent chronic neurological disorder is marked by recurring seizures due to atypical neuronal activity. The aim of this research work was to evaluate the comparative efficacy of peperomia pellucida and Diazepam on pain in pentylenetrazol induce Epileptic mice model. Forty albino mice weighing 19-35g divided into four groups (n=10) were used for this study: control group, the PTZ group (35mg/kg via subcutaneously), peperomia pellucida treated group (2mg/kg p.o) and Diazepam treated group (0.001ml/kg via p.o). Pentylenetetrazol (35mg/kg via subcutaneously) was used to induce epilepsy. All animals had access to food and water ad libitum. After administration for 14 days, epilepsy was induced and then neurobehavioural parameters were assessed using the hot plate test and formalin test. For the epileptic seizures result, peperomia pellucida treated group (2mg/kg p.o) had decreased duration of seizures, frequency of jerks, onset of tonic seizures and onset of seizures when compared to the pentylenetrazol (PTZ) treated group (P>0.001). For the hot plate test, results revealed that Peperomia pellucida treated group had a significant increased escape latency time and tail flick test time (P>0.05) indicating reduced pain sensitivity and enhanced pain tolerance. In the formalin test, results show that the PTZ + Peperomia pellucida treated group had a significant decrease (P>0.001) in before and after mediolateral and anteroposterior paw diameter measurements indicating that the PTZ + Peperomia pellucida had a significant low edema development.