COAGULATION PROFILE IN BLOOD DONORS AT THE BLOOD BANK UNIVERSITY COLLEGE HOSPITAL IBADAN OYO STATE NIGERIA.

Coagulation is a complex process by which blood forms clot. It is an important part of haemostasis (the cessation of blood loss from a damaged vessel). Disorders of coagulation can lead to an increased risk of bleeding (hemorrhage) or clotting (thrombosis). Haemostasis, defined as arrest of bleeding. This study was conducted to determine coagulation profile in blood donors at the blood bank University College Hospital, Ibadan Oyo State Nigeria. A prospective cross-sectional study was conducted at the blood bank University College Hospital Ibadan Oyo State Nigeria for a period of 3months on fifty blood donors (50) as subjects and fifty non-blood donors (50) as control. Their Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT) were analyzed using Automated coagulation profile analyzer, TEClot PT-S reagent with reference numbers A0230-010, A0230-040, A0230-100 and TEClot APTT-S with reference numbers were used A0300-025, A0300-050, A0320-050, A0320-100 respectively. The mean of the PT was significantly higher in the test group (16.20±1.77) compared to that of the control (14.30±1.11) (p=0.001). The mean of the INR was also significantly higher in the test group (1.32±0.18) compared to that of the control (1.13±0.11) (p=0.001). However, there was no significant difference between the mean of the APTT in the test subjects (33.82±3.18) compared to the control group (33.08±2.73) (p=0.129). In conclusion, it was found that the PT and INR of the test groups was significantly high while the APTT was not significant.