INVESTIGATION OF IN-VITRO ACTIVITY OF HONEY AGAINST CANDIDA ALBICANS AND ASPERGILLUS NIGER
Abstract
Honey exhibits antifungal properties against Aspergillus niger and Candida albicans, as demonstrated in various studies. Honey samples from different regions have shown broad-spectrum antifungal activity against Aspergillus niger and Candida albicans. Studies have reported varying zones of inhibition, with Aspergillus niger showing higher sensitivity to honey extracts. For instance, one study found a zone of inhibition of 22mm at 100% concentration for Aspergillus niger. Honey has been found effective even against Amphotericin B and Itraconazole-resistant Aspergillus species. Honey's acidity and hydrogen peroxide content contribute to its antimicrobial properties. The exact mechanism of action is still being researched, but studies suggest that honey disrupts microbial cell membranes and inhibits biofilm formation. Honey's antimicrobial and anti-biofilm properties make it a potential agent for wound care. Honey could be used as an adjunct therapy for fungal infections, particularly those resistant to conventional treatments
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