ASSESSMENT OF CARDIAC HISTOLOGY AND HEMATOLOGICAL PARAMETERS IN MYOCARDIAL TISSUES FOLLOWING MONOSODIUM GLUTAMATE ADMINISTRATION IN FEMALE WISTAR RATS
Abstract
This experimental study investigated the effects of chronic high-dose monosodium glutamate (MSG) administration on cardiac histology and hematological parameters in adult female Wistar rats. Fifteen rats were divided into three groups: control, low-dose MSG (300 mg/kg), and high-dose MSG (1000 mg/kg), and treated orally for 60 days. Hematological indices were assessed using standard laboratory methods, while cardiac tissues were processed and examined histologically using hematoxylin and eosin staining. Results revealed significant reductions in red blood cell count, hemoglobin concentration, packed cell volume, and white blood cell count in MSG-treated groups. Histological examination showed dose-dependent myocardial degeneration characterized by cardiomyocyte disorganization, fiber fragmentation, pyknotic nuclei, and interstitial fibrosis. The findings indicate that chronic high-dose MSG intake induces hematological alterations and myocardial damage, raising concerns about excessive dietary consumption.
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