PROTECTIVE EFFECTS OF LINALOOL ON IMATINIB-INDUCED TESTICULAR TOXICITY IN ALBINO MICE

Imatinib Mesylate is a targeted anticancer agent widely used in the treatment of chronic myeloid leukemia and other malignancies. Despite its therapeutic benefits, it has been associated with testicular toxicity, primarily through oxidative stress and disruption of testicular architecture. Linalool, a monoterpene alcohol found in essential oils of aromatic plants, possesses antioxidant, anti-inflammatory, and cytoprotective properties. This study was designed to evaluate the protective effects of Linalool against Imatinib-induced testicular damage in albino mice. Thirty male mice were divided into five groups: control, olive oil (vehicle), Imatinib (400 mg/kg), Imatinib + Linalool (400mg/kg), and Linalool only. Treatments were administered orally for two weeks. Testicular tissues were analyzed for oxidative stress markers, antioxidant enzyme activity, and histological integrity. Imatinib administration resulted in reduced antioxidant enzyme levels, elevated markers of lipid peroxidation, and structural degeneration of testicular tissue. Co-treatment with Linalool significantly restored biochemical parameters and preserved testicular histoarchitecture. The findings indicate that Linalool offers protective effects against Imatinib-induced testicular toxicity, likely through its antioxidant and tissue-preserving mechanisms. This study supports the potential role of Linalool as an adjunct therapeutic agent in mitigating reproductive side effects of chemotherapy.