PROTECTIVE EFFECT OF CRUDE EXTRACT OF ALLIUM CEPA (RED ONIONS)ON THE LIVER OF ADULT FEMALE WISTAR RAT FOLLOWING MANGANESE TOXICITY.
Abstract
This study investigates the protective effects of crude extract of Allium cepa (red onions)against manganese-induced hepatotoxicity in adult female Wistar rats.A total of 24 Wistar rats were divided into four groups (six rats each)based on their body weights:Group 1(control,70-90 g),Group 2(manganese only,120-130 g),Group 3 (manganese +quercetin,100-120 g),and Group 4(manganese +Allium cepa,90-100 g).Following a 21-day administration period,the rats were sacrificed,and liver samples were collected for histological examination after being fixed in formalin solution.Results indicated a significant weight loss in Group 2(manganese only) compared to the control group,while Groups 3(manganese +quercetin)and 4 (manganese +Allium cepa)exhibited relatively normal body weights.Histological analysis revealed normal hepatic cytoarchitecture in the control group,characterized by intact hepatocytes.In contrast,Group 2 displayed pronounced histoarchitectural distortion,evidenced by significant vacuolation and stromal changes.Group 3 (manganese +quercetin)also presented with histoarchitectural alterations,marked by vacuolation and congestion of the central vein.However,Group 4(manganese +
Allium cepa)showed relatively preserved hepatic architecture,highlighted by normal
central veins,sinusoids,hepatocytes,and Kupffer cells.These findings suggest that
Allium cepa possesses hepatoprotective properties against manganese-induced liver
toxicity,as indicated by the preservation of liver structure compared to both the
control and manganese-only groups
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