MODULATORY ROLES OF GARLIC EXTRACT IN CARDIOVASCULAR RISK FACTORS USING TOTAL ANTIOXIDANT ACTIVITY AND LIPID BIOMARKERS (MALONDIALDEHYDE AND CATALASE)
Abstract
Cardiovascular diseases (CVDs) remain one of the leading causes of mortality worldwide. Oxidative stress and lipid peroxidation are major contributors to the development and progression of cardiovascular disorders. Natural antioxidants from medicinal plants have gained increasing attention for their potential therapeutic benefits. Garlic (Allium sativum) is widely recognized for its cardioprotective and antioxidant properties. This study investigates the modulatory roles of garlic extract in cardiovascular risk factors by evaluating total antioxidant activity and lipid biomarkers, specifically malondialdehyde (MDA) and catalase (CAT). Garlic extract was administered to experimental samples, and biochemical analyses were conducted to determine antioxidant enzyme activities and levels of lipid peroxidation. Results indicated that garlic extract significantly increased catalase activity while reducing malondialdehyde levels, suggesting a decrease in oxidative stress and lipid peroxidation. These findings demonstrate that garlic possesses strong antioxidant properties that may help modulate cardiovascular risk factors and protect against oxidative damage. The study concludes that garlic extract could serve as a potential natural therapeutic agent in the prevention and management of cardiovascular diseases.
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