THERAPEUTIC EFFECTS OF KHAYA SENEGALENSIS FLAVONOID AND SAPONIN ON THE PARIETO-TEMPORAL CORTEX OF STROKE RAT MODEL
Abstract
Khaya senegalensis is the most I?Opular' African medicinal malicious plants and is used traditionally in the management of Jgleurodegeneraltive disorders. This study aims to investigate how Khaya senegalensis flavonoid|and saponin rfiitigate the cortical degeneration induced by amitriptyline. A total of eighty adult male wistar rats weighing 160g — 208mg/kg were grouped into 11 groups (n = 6): The experiment was divide!cli in 2 phases. Phase I: stroke induction, using a single dose of 1.2 mg/kg of AMT for 3 days. Phase II: treatment groups, the rats were subdivided into AMT group (Strok'f: rats), left untreated and 3 treatment groups, which were ireated with KS orally, at doses 0f 200, 300 and 400mg/kg body weight, designated as COMLip + AMT, COMwmp + AMT ana COMip + AMT respectively, for a period of two weeks. Control was administered with distilled water. After adi!ninistration the rats were euthanized using cervical dislocation and the brain were collected and fixed in 10% neutral buffered formalin for histological detection using -__Haematoxylir'-l and Eosin (H&E) Stains. Histological observation on the prefrontal cortex showed normal histoarchitecture in control rats (CTR group). AMT treated rats (AMT group) showed qllorphological changes in neurovascular unit, lymphocytic infiltration, severe degtf:nerated, psychotic nuclei, capillaries proliferation, cellular hypertrophy and perivascular edema and gliosis compared to control. Upon the administration of a combination of Khaya senegalénsz’s flavonoid and saponin at a dosage of 200mg/kg (LD), there was a discernible reduction in the severity of damage observed in the prefrontal cortex,
while at dose 300mg/kg (SD), treated rats showed mild and intact meninges. The most substantial improvements were observed at the [400mg/kg dose (HD), with less to normal orientation of cortical cells and the neurovascular unit. In conclusion, Khaya senegalensis flavonoid bark and saponin extracts have proven|to ameliorate induced degenerative changes in the parieto-temporal cortex of an{litriptyline—in Juced damage in adult wistar rats.
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