EFFECT OF ETHANOLIC LEAF EXTRACT OF CRASSULACEA AND BISOPROLOL ON APOPTOTIC MARKERS (CASPASE – 3 AND BCL – 2), TOTAL ANDCONJUGATED BILIRUBIN AND THE CYTOARCHITECTURE OF THE LIVER IN DOXORUBICIN INDUCED CARDIAC TOXICITY.
Abstract
This study aimed at investigating the effect of ethanolic leaf extract of crassulaceae and bisoprolol on apoptotic markers (caspase– 3, BCL – 2) and total and conjugated bilirubin and the cytoarchitecture of the liverindoxorubicininducedcardiactoxicityinwistarrat.Thirtyfive(35)wistarratsweighing110-190were divided into 5 groups of 7 rats each. Group 1( normal control), Group 2 (Cr only), Group 3 (Dox only), Group 4 (Dox +Cr), Group 5 (Dox+Bis),. Ethanolic leaf extract of Cr was administered orally at dose of 600mg/kgbwt.Doxorobucinwasadministeredintraperitoneallyatdoseof50mg/kg/bwt.Allthegroupswere givennormalratchowandwateradlibtum.Theregimenlastedfor28days.Thereafter,theanimals werevhen sacrificed using chloroform anesthesia. The blood was collected via cardiac puncture into sample bottles and centrifuged at 2500rpm for 10minutes. Serum were collected for laboratoryanalysis. Theresults shows a significant level (P
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